Also known as niacinamide, is the water-soluble, active form of vitamin B3. Nicotinamide is naturally present in small quantities in yeast, lean meats, fish, nuts, and legumes. Nicotinamide has anti-inflammatory properties and may be taken orally or else as an ingredient in many skin care products. Topically it can improve acne by its anti-inflammatory action and by reducing sebum. It also improves skin barrier function by decreasing water loss through the epidermis. Nicotinamide taken orally at a dose of 500mg twice a day can significantly reduce the chances of developing actinic keratosis (pre-cancerous lesions) and non-melanoma skin cancers (NMSC).
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